Friday, September 14, 2012

Beyond Nicoderm: Transdermal Patches See Growth

It is anticipated that the transdermal/transmucosal drug delivery market will  continue to grow beyond the smoking cessation technology that first brought them to the marketplace, according to Kalorama Information's just-published report on this topic.   The market for drugs that use technologies to deliver therapeutics through the skin is expected to be driven by various factors including the loss of patent protection for blockbuster drugs and the need to avoid the first pass effects  of oral drug delivery. 

Additionally, with an added focus on active transdermal technologies, new applications will likely cause a resurgence of interest in transdermal delivery of products. Recent advances in biotechnology and molecular biology have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of disease. However, such potential is severely compromised by significant obstacles to delivery these drugs into the body. These obstacles mean that drug delivery and targeting is now recognized as the key to effective development of many therapeutics. Transdermal and transmucosal drug delivery systems continue to gain market acceptance as a preferred method of administration.

 Interest in transdermal/transmucosal drug delivery dropped until the early 1970s. In 1981 the first dermal patches, Transderm-Scop for scopolamine (ALZA) and the Transderm-Nitro (ALZA), were launched on the market. Nitro-Dur (Key) and Nitro-Disc (Searle) followed in 1982, and in 1985, Boehringer Ingelheim released Catapress-TTS for clonidine, using ALZA’s drug delivery technology. This spurred a number of transdermal product offerings including::   Estraderm (CIBA) for estradiol, Duragesic (Janssen) for fentanyl, Testoderm (ALZA) for testosterone, Minitran (3M) for nitroglycerin.

These products and more are covered in The World Market for Transdermal Drugs, from Kalorama Information.