The trend of decreasing cost has actually been accelerating on a logarithmic scale; if it continues, it would lead to a cost of only $10 per genome in around five years. Benchtop next-generation sequencers are now priced at $50k to $100k, compared to the $500k to $700k for higher end systems.
The ability to pool multiple individuals’ samples in one run has allowed further savings of time and money. As a result, sequencers are expected to see widespread adoption in the next several years into a much broader range of clinical applications than before, as the scientific and regulatory hurdles are gradually addressed. The following areasprovide some examples of the clinical areas showing promise.
- HLA/MHC Complex
- Pathogen Detection and Subtyping
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